Steroids and derivatives
Medchemexpress LLC Estrone | 53-16-7 | 99.9% | 5 G
Estrone (E1) is a natural estrogenic hormone and the primary endogenous estrogen in postmenopausal women. It is produced by several tissues, particularly adipose tissue, through the aromatization of androstenedione.
- Natural estrogenic hormone and endogenous estrogen
- Produced in adipose tissue
- Targets estrogen receptor and ERR
- Relevant for endocrinology and cancer research
- Categorized as a natural product, inhibitor, or agonist
- Involved in vitamin D related and nuclear receptor pathways
- Involved in metabolic enzyme and protease pathways
- Stable as powder at -20°C for 3 years and 4°C for 2 years
- Stable in solvent at -80°C for 6 months and -20°C for 1 month
- Soluble in DMSO
Medchemexpress LLC Estrone | 53-16-7 | 100.0% | 1 G
Estrone (E1) is a natural estrogenic hormone and the main representative of endogenous estrogens. It is produced by several tissues, particularly adipose tissue, and results from the aromatization of androstenedione in fat cells. It is the main endogenous estrogen in postmenopausal women.
- Also known as E1 or Oestrone.
- Classified as a human endogenous metabolite.
- Appears as a white to off-white solid.
- Has a molecular weight of 270.37 and a chemical formula of C18H22O2.
- Insoluble in H2O (< 0.1 mg/mL) but soluble in DMSO (25 mg/mL).
- For research use only.
Apexbio Technology LLC Estrone 53-16-7 5g
Estrone (53-16-7) is a naturally occurring estrogen that modulates estrogen receptor-mediated signaling pathways It is primarily synthesized in ovarian and adipose tissues and participates in the regulation of estrogen-dependent cellular and physiological processes Estrone exerts its biological activity primarily through binding and activating estrogen receptors Experimental model activity type and key metric (IC50/EC50) are not specified Based on these pharmacological properties estrone holds research potential in studies of estrogen receptor activation reproductive endocrinology menopausal hormone transitions and estrogen-dependent signaling pathways and diseases
Medchemexpress LLC Estrone sulfate sodium | 438-67-5 | 99.8% | 372.41 | 1 ML
Estrone sulfate sodium is an inactive endogenous estrogen that can be converted into Estrone and Estradiol. It is a substrate of the OATP1B3 transporter and is applicable to breast cancer-related research. It stimulates the growth of nitrosomethylurea-induced mammary tumors and colony formation of dispersed nitrosomethylurea mammary cells.
- Inactive endogenous estrogen
- Converted to estrone and estradiol
- Substrate of OATP1B3 transporter
- Stimulates mammary tumor growth
- Applicable to breast cancer research
Medchemexpress LLC Estrone sulfate potassium | 1240-04-6 | 99.9% | 388.52 | 1 MG
Estrone sulfate potassium | 1240-04-6 | 99.9% | 388.52 | 1 MG
Medchemexpress LLC Alpha-Estradiol | 57-91-0 | 99.9% | 5 G
Alpha-Estradiol is identified as a weak estrogen and a 5α-reductase inhibitor. It is employed as a topical medication for treating androgenic alopecia.
- Weak estrogen.
- Acts as a 5α-reductase inhibitor, preventing testosterone metabolism catalyzed by 5 alpha-reductase.
- Attenuates LPS-induced inflammatory markers in mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes, and differentiated 3T3-L1 adipocytes through an ERα-dependent mechanism.
- Decreases NFκB-p65 and elevates ERα protein expression.
- Significantly reduces the central avascular/total retina area in mouse pups.
- Lowers malondialdehyde (MDA) levels, the number of NADPH-oxidase-positive cells, NADPH oxidase concentration, and activity in the retinas of hyperoxia-exposed pups.
Medchemexpress LLC Estradiol enanthate (E2EN) | 4956-37-0 | 98.1% | 100 MG
Estradiol enanthate (E2EN) is a shorter-acting estrogen. It is an injectable contraceptive when combined with Dihydroxyprogesterone acetophenide. Estradiol enanthate facilitates withdrawal bleeding, mimicking a menstruation-like pattern.
- Shorter-acting estrogen.
- Functions as an injectable contraceptive in combination with Dihydroxyprogesterone acetophenide.
- Promotes withdrawal bleeding, in a pattern similar to menstruation.
- Changes the corporal characteristics of male rats to resemble female rats.
- In a study, it increased plasma urea and creatinine concentration compared to the control group.
Medchemexpress LLC Alpha-Estradiol | 57-91-0 | MFCD00064144 | 99.5% | 1 G
Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor. It is utilized as a topical medication for the treatment of androgenic alopecia and is classified as a human endogenous metabolite.
- Weak estrogen and 5 alpha-reductase inhibitor
- Inhibits testosterone metabolism catalyzed by 5 alpha-reductase
- Attenuates LPS-induced inflammatory markers in various cell types
- Decreases NFκB-p65 and increases ER alpha protein expression
- Reduces central avascular/total retina area in mouse models
- Decreases malondialdehyde (MDA) levels in hyperoxia-exposed pups
- Reduces NADPH-oxidase-positive cells, concentration, and activity in pup retinas
Medchemexpress LLC Estradiol-d2 | 53866-33-4 | >98.0% | 1 MG
Estradiol-d2 is the deuterium-labeled Estradiol. Estradiol is a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. It upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway. It can be used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium-labeled estradiol
- Vital for fertility and secondary sexual characteristics
- Upregulates IL-6 expression via ERβ pathway
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Apexbio Technology LLC α-Estradiol 57-91-0 50mg
alpha-Estradiol (57-91-0) is a small-molecule inhibitor targeting 5 -reductase the enzyme responsible for converting testosterone to dihydrotestosterone (DHT) It is designed to inhibit 5 -reductase activity thereby modulating androgen metabolism and androgen-related signaling pathways alpha-Estradiol exerts its biological activity primarily through enzyme inhibition In reported experimental studies alpha-Estradiol demonstrates inhibitory activity against 5 -reductase with an IC50 value ranging from approximately 1 to 10 M though the precise value may depend on assay conditions Based on these pharmacological properties alpha-Estradiol holds research potential in the treatment and study of androgenetic alopecia
Medchemexpress LLC Alpha-estradiol-d2 | 81586-94-9 | 99.75% | 5 MG
Alpha-Estradiol-d2 is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor used as a topical medication in the treatment of androgenic alopecia. Deuteration has gained attention due to its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Alpha-Estradiol (Standard) | 57-91-0 | 99.9% | 50 MG
Alpha-Estradiol (Standard) is the analytical standard of Alpha-Estradiol, intended for research and analytical applications. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor used as a topical medication in the treatment of androgenic alopecia.
- Analytical standard for research and analytical applications
- Used in HPLC, GC, and MS experiments
- Weak estrogen and 5α-reductase inhibitor
- Solid appearance, white to off-white
- Stable under recommended storage conditions
Cayman Chemical Ethynyl Estradiol
An estrogen receptor agonist (EC50 = 8.5 pM in a reporter assay using T47D cells); reduces serum cholesterol levels and femur bone mass and increases uterine mass in an OVX rat model of postmenopause at 0.1 mg/kg per day; has been found in wastewater effluent; prevents secondary sexual development in male fathead minnows and increases the numbers of intersex fish at 4 ng/l
Medchemexpress LLC Estradiol (Standard) | 50-28-2 | MFCD00003693 | 99.98% | 100 MG
Estradiol (Standard) is the analytical standard of Estradiol, a steroid hormone and the major female sex hormone. This compound can up-regulate the expression of neural markers of human endometrial stem cells (hEnSCs) and promote their neural differentiation. It is used in research for cancers, neurodegenerative diseases, and neural tissue engineering.
- Used as a reference standard for assays
- Utilized in qualitative, quantitative, and methodological research experiments
- Promotes neural differentiation of human endometrial stem cells
- Supports research in cancers, neurodegenerative diseases, and neural tissue engineering
- Commonly used in HPLC, GC, and MS applications