Steroids and derivatives
Medchemexpress LLC Dexamethasone (Standard) | 50-02-2 | MFCD00064136 | 99.0% | 392.46 | 100 MG
Dexamethasone (Standard) | 50-02-2 | MFCD00064136 | 99.0% | 392.46 | 100 MG
Medchemexpress LLC Hydrocortisone cypionate | 508-99-6 | 486.64 | 5 MG
Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is intended for research use only.
- Down-regulates GR transcript in hCMEC/D3 cells in a dose-dependent manner.
- Supplementation leads to a significant increase in TER across the hCMEC/D3 monolayer.
- Treated dendritic cells (DCs) exhibit decreased expression of MHC II molecules, costimulatory molecule CD86, and DC-specific marker CD83.
- Treated dendritic cells (DCs) show strongly reduced IL-12 secretion.
- Treated dendritic cells (DCs) inhibit IFN-γ production but induce increased release of IL-4.
- Reduces post-ischemic oxidative stress, perfusion pressure, and transudate formation.
- Inhibits post-ischemic shedding of syndecan-1, heparan sulfate, and hyaluronan.
- Inhibits histamine release from mast cells.
Medchemexpress LLC Dexamethasone (Water Soluble) | 50-02-2 | MFCD00064136 | 98.9% | 1493.5 g/mol | 500 MG
Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone and acts as a glucocorticoid receptor agonist and apoptosis inducer. It is used in experimental animals to construct models of muscle atrophy, hypertension, and depression. This compound can inhibit the production of inflammatory miRNA-155 exosomes in macrophages and significantly reduce the expression of inflammatory factors in neutrophils and monocytes, with potential for COVID-19 research.
- Regulates transcription factors like activator protein-1, nuclear factor-AT, and nuclear factor-kB.
- Potently inhibits granulocyte-macrophage colony stimulating factor (GM-CSF) release from A549 cells.
- Used in animal modeling for muscle atrophy, hypertension, and depression.
Medchemexpress LLC Cortisone acetate (Standard) | 50-04-4 | 99.4% | 402.48 | 50 MG
Cortisone acetate (Standard) serves as an analytical standard for research and analytical applications. This compound, an oxidized metabolite of Cortisol, functions as an immunosuppressant and anti-inflammatory agent. It is commonly utilized in qualitative, quantitative, and methodological research experiments across various techniques.
- Analytical standard for research
- Reference standard for assays
- Immunosuppressant properties
- Anti-inflammatory agent
- Used in HPLC, GC, and MS experiments
Medchemexpress LLC Hydrocortisone 17-valerate | 57524-89-7 | 98.0% | 100 MG
Hydrocortisone 17-valerate is a derivative of Hydrocortisone and a corticosteroid ester. It possesses anti-inflammatory effects.
- Has anti-inflammatory effects.
Apexbio Technology LLC Dexamethasone (DHAP) 50-02-2 10mM (in 1mL DMSO)
Dexamethasone (DHAP) is a synthetic glucocorticoid commonly utilized in biomedical research due to its potent anti-inflammatory function and immunomodulatory effects It exerts its mechanism through glucocorticoid receptor-mediated transcriptional modulation resulting in reduced transcriptional activity of NF- B signaling pathways in dendritic cells (DC) thus inhibiting DC maturation and activation This compound is frequently employed in experiments investigating immune regulation inflammation and cell differentiation processes including induction of differentiation in human mesenchymal stem cells (MSCs) Additionally dexamethasone is used in cancer cell biology research as it promotes autophagy in acute lymphoblastic leukemia-derived cell lines Reported IC50 values for dexamethasone-mediated inhibition of cellular inflammation responses typically range from 2 50 nM depending on specific cellular models and experimental conditions
Medchemexpress LLC Dexamethasone (Water Soluble) | 50-02-2 | 98.9% | 50 MG
Dexamethasone (Hexadecadrol) Water Soluble is a water-soluble form of Dexamethasone, acting as a glucocorticoid receptor agonist and apoptosis inducer. It serves as a common disease inducer in experimental animals, suitable for models of muscle atrophy, hypertension, and depression. It also inhibits inflammatory miRNA-155 exosomes and reduces inflammatory factors, with potential in COVID-19 research.
- Glucocorticoid receptor agonist and apoptosis inducer
- Used for muscle atrophy, hypertension, and depression models
- Inhibits inflammatory miRNA-155 exosomes; reduces inflammatory factors
- Potential for COVID-19 research
- Solubility in H2O: ≥ 100 mg/mL
- Modulates key transcription factors
- Potently inhibits GM-CSF release
Medchemexpress LLC Hydrocortisone acepo 5mg | 74050-20-7 | 460.56 | C26H36O7 | 5 MG
Hydrocortisone aceponate (Hydrocortisone 17-propionate 21-acetate) is a potent topical glucocorticoid supplied as a research-grade analytical standard in solid powder and solution forms. It is used for studies of glucocorticoid receptor activity and for research into inflammatory dermatoses. Molecular formula C26H36O7; molecular weight 460.56; CAS 74050-20-7.
- Potent topical glucocorticoid for dermatoses research.
- Provided as powder (solid) and as 10 mM solution in DMSO.
- Intended for research and analytical applications (research use only).
- Target: glucocorticoid receptor; pathway: immunology/inflammation.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
- Analytical documentation available: COA, HNMR, LCMS.
Selleck Chemical LLC Hydrocortisone acetate
Hydrocortisone Acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone a corticosteroid with anti-inflammatory and immunosuppressive properties
Selleck Chemical LLC Dexamethasone 21-phosphate
Dexamethasone phosphate disodium is a glucocorticoid receptor agonist with both anti-inflammatory and anti-oxidative effects
Selleck Chemical LLC Fluocinolone Acetonide 100mg 67-73-2 Flucort-N
Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic glucocorticoid receptor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Prednisone acetate
Prednisone acetate (Betapar Cortan Deltasone Fernisone Meticorten Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties
Medchemexpress LLC HY-107830 100mg Medchemexpress, Methyl cholate CAS:1448-36-8 Purity:>98%
Medchemexpress, HY-107830 100mg Methyl cholate CAS:1448-36-8 Methyl Cholate is methyl ester form of Cholic acid. Cholic acid is one of the major bile acids produced by the liver, where it is synthesized from cholesterol. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cambridge Isotope Laboratories 11-Dehydrocorticosterone (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
11-Dehydrocorticosterone (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
